Mutation-driven β-lactam resistance mechanisms among contemporary ceftazidime-nonsusceptible Pseudomonas aeruginosa isolates from U.S. hospitals.

@article{Castanheira2014MutationdrivenR,
  title={Mutation-driven β-lactam resistance mechanisms among contemporary ceftazidime-nonsusceptible Pseudomonas aeruginosa isolates from U.S. hospitals.},
  author={M. S. A. Castanheira and Janet C Mills and David John Farrell and Ronald N. Jones},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 11},
  pages={6844-50}
}
OprD loss and hyperexpression of AmpC, MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY-OprM were evaluated among 120 Pseudomonas aeruginosa isolates collected during 2012 in U.S. hospitals and selected based on ceftazidime MIC values (1 to >32 μg/ml). AmpC derepression (10-fold greater than that with the control) and OprD loss (decreased/no band) were the… CONTINUE READING