Mutation-biased adaptation in a protein NK model.

@article{Stoltzfus2006MutationbiasedAI,
  title={Mutation-biased adaptation in a protein NK model.},
  author={Arlin Stoltzfus},
  journal={Molecular biology and evolution},
  year={2006},
  volume={23 10},
  pages={1852-62}
}
Evolutionary trends responsible for systematic differences in genome and proteome composition have been attributed to GC:AT mutation bias in the context of neutral evolution or to selection acting on genome composition. A possibility that has been ignored, presumably because it is part of neither the Modern Synthesis nor the Neutral Theory, is that mutation may impose a directional bias on adaptation. This possibility is explored here with simulations of the effect of a GC:AT bias on amino acid… CONTINUE READING
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