Mutation at the APRT locus in Friend erythroleukaemia cells. 1. Mutation rates and properties of mutants.

@article{McKenna1987MutationAT,
  title={Mutation at the APRT locus in Friend erythroleukaemia cells. 1. Mutation rates and properties of mutants.},
  author={Paul G. McKenna and Patrick E. Ward},
  journal={Mutation research},
  year={1987},
  volume={180 2},
  pages={267-71}
}
Spontaneous mutation at the adenine phosphoribosyl transferase (APRT) locus in clone 707 of the Friend cell line was examined. The frequency of cells resistant to 2,6-diaminopurine (DAP) was found to be 2.6 X 10(-5) with a mutation rate of 1.81 X 10(-6) cell-1 generation-1. APRT activities in 9 DAP-resistant clones were found to vary between 0 and 27% the… CONTINUE READING