Mutation assay of the novel gene DOG1 in gastrointestinal stromal tumors (GISTs)

@article{Miwa2008MutationAO,
  title={Mutation assay of the novel gene DOG1 in gastrointestinal stromal tumors (GISTs)},
  author={S. Miwa and Takahiko Nakajima and Y. Murai and Y. Takano and T. Sugiyama},
  journal={Journal of Gastroenterology},
  year={2008},
  volume={43},
  pages={531-537}
}
BackgroundRecently, the novel gene DOG1 has been found to be overexpressed in most gastrointestinal stromal tumors (GISTs) specifically within the field of soft tissue tumors. DOG1 might play a role in development of GISTs and have potential as a diagnostic marker and therapeutic target, but the biological function and the overexpression mechanism have not yet been investigated. In this study we examined whether the DOG1 gene mutation occurs as with the KIT gene and PDGFRA gene.MethodsWe… Expand
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