Mutation and selection within the individual

@article{Otto1998MutationAS,
  title={Mutation and selection within the individual},
  author={Sarah P. Otto and Ian M. Hastings},
  journal={Genetica},
  year={1998},
  volume={102},
  pages={507-524}
}
Selection within the individual may have played a critical and creative role in evolution, boosting the survival chances of mutations beneficial to the cell and the individual, hindering the spread of deleterious mutations, and reducing the genetic load imposed on the population. We review the literature and present new results to describe the effects of cell-lineage selection on the rate and fixation probability of new mutations. Cell-lineage selection can alter these quantities by several… CONTINUE READING

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