Mutation and polymorphism in the EGFR-TK domain associated with lung cancer.

@article{Zhang2006MutationAP,
  title={Mutation and polymorphism in the EGFR-TK domain associated with lung cancer.},
  author={Weiping Zhang and Laura P. Stabile and Phouthone Keohavong and Marjorie Romkes and Jennifer R Grandis and Anne M. Traynor and Jill M. Siegfried},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2006},
  volume={1 7},
  pages={
          635-47
        }
}
BACKGROUND The epidermal growth factor receptor (EGFR) is involved in the development and progression of lung cancer. Somatic EGFR mutations are predictors of response to treatment with EGFR tyrosine kinase (TK) inhibitors (TKIs) for lung cancer, especially among never smokers. EGFR mutations may occur independently of other genetic alterations. METHODS The authors sequenced the EGFR-TK domain and the K-ras and p53 genes from lung tumor tissues from 44 never smokers and 46 smokers. A case… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Similar Papers

Loading similar papers…