Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome.

@article{Migdalovich2011MutationAG,
  title={Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome.},
  author={Dimitry Migdalovich and Arthur J. Moss and Coeli M. B. Lopes and Jason Costa and Gregory M Ouellet and Alon Barsheshet and Scott McNitt and Slava Polonsky and Jennifer L. Robinson and Wojciech Zareba and Michael J. Ackerman and Jesaia Benhorin and Elizabeth S. Kaufman and Pyotr G. Platonov and Wataru Shimizu and Jeffrey Allen Towbin and G. Michael Vincent and Arthur A. M. Wilde and Ilan Goldenberg},
  journal={Heart rhythm},
  year={2011},
  volume={8 10},
  pages={1537-43}
}
BACKGROUND Men and women with type 2 long QT syndrome (LQT2) exhibit time-dependent differences in the risk for cardiac events. We hypothesized that data regarding the location of the disease-causing mutation in the KCNH2 channel may affect gender-specific risk in LQT2. OBJECTIVE This study sought to risk-stratify LQT2 patients for life-threatening cardiac events based on clinical and genetic information. METHODS The risk for life-threatening cardiac events from birth through age 40 years… CONTINUE READING
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