Mutation and expression of PDGFRA and KIT in malignant peripheral nerve sheath tumors, and its implications for imatinib sensitivity.

Abstract

Platelet-derived growth factor receptor alpha (PDGFRalpha) and c-Kit are receptor tyrosine kinases. Both are targets of the tyrosine kinase inhibitor imatinib mesylate which is approved for treatment of some cancers. In order to assess the role of PDGFRalpha and c-Kit in malignant peripheral nerve sheath tumours (MPNST) we examined human tumours for… (More)

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Cite this paper

@article{Holtkamp2006MutationAE, title={Mutation and expression of PDGFRA and KIT in malignant peripheral nerve sheath tumors, and its implications for imatinib sensitivity.}, author={Nikola Holtkamp and Ali Fuat Okuducu and Jana Mucha and Anastasia Afanasieva and Christian Hartmann and Isis Atallah and Lope Est{\'e}v{\'e}z-Schwarz and Christian Mawrin and Reinhard Edgar Friedrich and Victor-Felix Mautner and Andreas von Deimling}, journal={Carcinogenesis}, year={2006}, volume={27 3}, pages={664-71} }