Mutation and Selection of Prions

  title={Mutation and Selection of Prions},
  author={Charles Weissmann},
  booktitle={PLoS pathogens},
Prion diseases, or transmissible spongiform encephalopathies (TSEs), occur naturally in several species, including humans, cattle, sheep, and deer, and can be transmitted experimentally to many others. Typically, incubation times are relatively long, extending to 40 years or more in humans; however, after appearance of clinical symptoms, death mostly ensues within less than a year, as a consequence of neurodegeneration accompanied by accumulation of abnormal conformers of the host protein PrP… CONTINUE READING
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