Mutation analysis of transforming growth factor beta type II receptor, Smad2, Smad3 and Smad4 in esophageal squamous cell carcinoma.

@article{Osawa2000MutationAO,
  title={Mutation analysis of transforming growth factor beta type II receptor, Smad2, Smad3 and Smad4 in esophageal squamous cell carcinoma.},
  author={Hiroshi Osawa and Yoshinori Shitara and Hiroki Shoji and Akira Mogi and Hiroyuki Kuwano and Koichi Hagiwara and Seiichi Takenoshita},
  journal={International journal of oncology},
  year={2000},
  volume={17 4},
  pages={723-8}
}
Mutations of the transforming growth factor beta type II receptor (TGFbetaRII) gene and Smad family genes have been observed in several human cancers. However, there has been no report on mutation analysis of the entire coding regions of these genes in esophageal cancer, and the role of these genes in the development of esophageal cancer remains unknown. We performed polymerase chain reaction-single strand conformation polymorphism analysis of TGFbetaRII, Smad2, Smad3 and Smad4 genes and… CONTINUE READING

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