Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression.

@article{Calistri2005MutationAO,
  title={Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression.},
  author={Daniele Calistri and Claudia Rengucci and Ian Seymour and Arturo Lattuneddu and Anna Maria Polifemo and F. Monti and Luca Saragoni and Dino Amadori},
  journal={Journal of cellular physiology},
  year={2005},
  volume={204 2},
  pages={484-8}
}
Gene mutations in APC, K-ras, and p53 are thought to be essential events for colorectal cancer development. Recent data seem to indicate that K-ras and p53 mutations rarely co-exist in the same tumor, indicating that these alterations do not represent a synergistic evolutionary pathway. Moreover, an inverse relation between K-ras gene activation and BRAF mutations has been demonstrated, suggesting alternative pathways for colorectal cancer transformation. To reconstruct the chronological… CONTINUE READING

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