Mutation analysis of gene PAX6 in human gliomas.

@article{Pinto2007MutationAO,
  title={Mutation analysis of gene PAX6 in human gliomas.},
  author={Giovanny Rebouças Pinto and Carlos Afonso Clara and M J Parreira Santos and Jos{\'e} Reinaldo Almeida and Rommel Rodr{\'i}guez Burbano and Jean Christophe Rey and Cacilda Casartelli},
  journal={Genetics and molecular research : GMR},
  year={2007},
  volume={6 4},
  pages={
          1019-25
        }
}
Gliomas are the most common tumors of the central nervous system. In spite of the marked advances in the characterization of the molecular pathogenesis of gliomas, these tumors remain incurable and, in most of the cases, resistant to treatments, due to their molecular heterogeneity. Gene PAX6, which encodes a transcription factor that plays an important role in the development of the central nervous system, was recently recognized as a tumor suppressor in gliomas. The objective of the present… CONTINUE READING

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