Mutation analysis of RAP1 gene in papillary thyroid carcinomas.


In human papillary thyroid carcinomas (PTCs), the genetic alterations of RET/PTC, RAS or BRAF account for about 60-70% of cases with practically no overlap, providing strong genetic evidence that constitutive active signaling along MAPK pathway is critical for PTC development. In the remaining 30-40% of the cases, the oncogenes are still unknown. RAP1 is a… (More)


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@article{Matsuse2009MutationAO, title={Mutation analysis of RAP1 gene in papillary thyroid carcinomas.}, author={Michiko Matsuse and Norisato Mitsutake and Tatiana I. Rogounovitch and Vladimir A. Saenko and Yuka Nakazawa and Pavel O Rumyantsev and Eugeny F Lushnikov and Keiji Suzuki and Shunichi Yamashita}, journal={Endocrine journal}, year={2009}, volume={56 1}, pages={161-4} }