Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.

@article{Ikediobi2006MutationAO,
  title={Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.},
  author={Ogechi N. Ikediobi and Helen Margaret Davies and Graham Bignell and Sarah J Edkins and Claire E. Stevens and Sarah O'meara and Thomas Santarius and Tim Avis and Syd Barthorpe and Lisa Brackenbury and Gemma Buck and Adam Butler and Jody Clements and Jennifer Cole and E. Dicks and S. Forbes and Kristian A. Gray and Kelly A. Halliday and Rachel Ann Harrison and Katy Hills and Jonathan W. Hinton and Chris Hunter and Andy Jenkinson and David Rees Jones and Vivienne Kosmidou and Richard H. Lugg and Andrew Menzies and Tatiana Mironenko and Adrian G. Parker and Janet Elise. Perry and Keiran M Raine and David G. Richardson and Rebecca Shepherd and Alex Small and Raffaella Smith and Helen M. Solomon and Philip J. Stephens and Jon W. Teague and Calli Tofts and Jennifer Varian and T. Webb and Sofie West and Sara Widaa and Andy Yates and William C. Reinhold and John N. Weinstein and Michael R. Stratton and P. Andrew Futreal and R. Wooster},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 11},
  pages={
          2606-12
        }
}
The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is a widely used resource. The NCI-60 has been characterized pharmacologically and at the molecular level more extensively than any other set of cell lines. However, no systematic mutation analysis of genes causally implicated in oncogenesis has been reported. This study reports the sequence analysis of 24 known cancer genes in the NCI-60 and an assessment of 4 of the 24… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1985
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2006
VIEW 1 EXCERPT

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