Mutation Rates and Intrinsic Fidelity of Retroviral Reverse Transcriptases

Abstract

Retroviruses are RNA viruses that replicate through a DNA intermediate, in a process catalyzed by the viral reverse transcriptase (RT). Although cellular polymerases and host factors contribute to retroviral mutagenesis, the RT errors play a major role in retroviral mutation. RT mutations that affect the accuracy of the viral polymerase have been identified… (More)
DOI: 10.3390/v1031137

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Cite this paper

@inproceedings{MenndezArias2009MutationRA, title={Mutation Rates and Intrinsic Fidelity of Retroviral Reverse Transcriptases}, author={Luis Men{\'e}ndez-Arias}, booktitle={Viruses}, year={2009} }