Mutation C677T in the methylenetetrahydrofolate reductase gene is associated with male infertility in an Indian population.

@article{Singh2005MutationCI,
  title={Mutation C677T in the methylenetetrahydrofolate reductase gene is associated with male infertility in an Indian population.},
  author={Kalpana Singh and Shrawan Kumar Singh and Ravindra Sah and Indu Shekhar Singh and R. Raja Raman},
  journal={International journal of andrology},
  year={2005},
  volume={28 2},
  pages={115-9}
}
A mutation (C677T) in the gene, MTHFR, is known to increase susceptibility to various multifactorial disorders. In order to assess this single nucleotide polymorphism (SNP) as risk factor for idiopathic male infertility, a case-control study was done on an Indian population. DNA from 151 cases of non-obstruction, idiopathic oligo-/azoospermia and 200 fertile males (controls) was polymerase chain reaction amplified using site-specific primers, and analysed for the mutation following HinfI… CONTINUE READING

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