Mutation Biases and Mutation Rate Variation Around Very Short Human Microsatellites Revealed by Human–Chimpanzee–Orangutan Genomic Sequence Alignments

@article{Amos2010MutationBA,
  title={Mutation Biases and Mutation Rate Variation Around Very Short Human Microsatellites Revealed by Human–Chimpanzee–Orangutan Genomic Sequence Alignments},
  author={W. Amos},
  journal={Journal of Molecular Evolution},
  year={2010},
  volume={71},
  pages={192-201}
}
  • W. Amos
  • Published 2010
  • Biology, Medicine
  • Journal of Molecular Evolution
I have studied mutation patterns around very short microsatellites, focusing mainly on sequences carrying only two repeat units. By using human–chimpanzee–orangutan alignments, inferences can be made about both the relative rates of mutations and which bases have mutated. I find remarkable non-randomness, with mutation rate depending on a base’s position relative to the microsatellite, the identity of the base itself and the motif in the microsatellite. Comparing the patterns around (AC)2 with… Expand
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