Mutating the CX3C Motif in the G Protein Should Make a Live Respiratory Syncytial Virus Vaccine Safer and More Effective.

@article{BoyogluBarnum2017MutatingTC,
  title={Mutating the CX3C Motif in the G Protein Should Make a Live Respiratory Syncytial Virus Vaccine Safer and More Effective.},
  author={Seyhan Boyoglu-Barnum and Sean O. Todd and J. R. Meng and Thomas R Barnum and Tatiana Chirkova and Lia M. Haynes and Samadhan J. Jadhao and Ralph A Tripp and Antonius G P Oomens and Martin L Moore and Larry J. Anderson},
  journal={Journal of virology},
  year={2017},
  volume={91 10}
}
Respiratory syncytial virus (RSV) belongs to the family Paramyxoviridae and is the single most important cause of serious lower respiratory tract infections in young children, yet no highly effective treatment or vaccine is available. Through a CX3C chemokine motif (182CWAIC186) in the G protein, RSV binds to the corresponding chemokine receptor, CX3CR1. Since RSV binding to CX3CR1 contributes to disease pathogenesis, we investigated whether a mutation in the CX3C motif by insertion of an… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Respiratory Syncytial Virus Vaccine Approaches: a Current Overview

  • Current Clinical Microbiology Reports
  • 2017
VIEW 6 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 65 REFERENCES

CX 3 CR 1 is expressed in differentiated human ciliated airway cells and co - localizes with respiratory syncytial virus on cilia in a G protein - dependent man

ML Moore, MH Chi, +10 authors RS Peebles
  • PLoS One
  • 2015

Similar Papers

Loading similar papers…