Mutated mitogen-activated protein kinase: a tumor rejection antigen of mouse sarcoma.

@article{Ikeda1997MutatedMP,
  title={Mutated mitogen-activated protein kinase: a tumor rejection antigen of mouse sarcoma.},
  author={Hideyuki Ikeda and Noriko Ohta and Koichi Furukawa and H. Miyazaki and Ling-mei Wang and Kagemasa Kuribayashi and L. John Old and Hiroshi Shiku},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 12},
  pages={6375-9}
}
The molecular basis of the polymorphic tumor rejection antigens of chemically induced sarcomas of inbred mice remains a mystery, despite the discovery of these antigens over 40 years ago and their critical importance to the foundation of tumor immunology. In an analysis of a panel of BALB/c 3-methylcholanthrene-induced tumors, we identified one tumor, CMS5, that elicited a strong cytotoxic T cell response with exquisite specificity for CMS5. A stable cloned line of T cells with this specificity… CONTINUE READING

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