Mutated in colorectal cancer protein modulates the NFκB pathway.

  title={Mutated in colorectal cancer protein modulates the NFκB pathway.},
  author={Nicholas D Sigglekow and Laurent Pangon and Tilman Brummer and Mark Molloy and Nicholas J. Hawkins and Robyn Lynne Ward and Elizabeth A. Musgrove and Maija R. J. Kohonen-Corish},
  journal={Anticancer research},
  volume={32 1},
BACKGROUND The tumour suppressor gene 'mutated in colorectal cancer' (MCC) is silenced through promoter methylation in colorectal cancer and has been implicated as a regulator of the nuclear factor kappa B (NFκB) pathway. Therefore, we aimed to determine whether MCC modulates NFκB activation in colorectal cancer. MATERIALS AND METHODS NFκB activation was assessed using luciferase reporter assays in colorectal cancer cells in vitro. MCC methylation was analysed in primary tumour specimens from… CONTINUE READING
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