Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.

@article{Efstathiou1999MutatedEC,
  title={Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.},
  author={Jason Alexander Efstathiou and Dongfang Liu and James M D Wheeler and Hee - Cheol Ezra Kim and Nicholas Beck and M. H. Mohamed Ilyas and Anastasios J. Karayiannakis and N. J. M. C. Mortensen and W. A. Kmiot and Raymond J Playford and Massimo Pignatelli and Walter F. Bodmer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 5},
  pages={2316-21}
}
Epithelial (E)-cadherin and its associated cytoplasmic proteins (alpha-, beta-, and gamma-catenins) are important mediators of epithelial cell-cell adhesion and intracellular signaling. Much evidence exists suggesting a tumor/invasion suppressor role for E-cadherin, and loss of expression, as well as mutations, has been described in a number of epithelial cancers. To investigate whether E-cadherin gene (CDH1) mutations occur in colorectal cancer, we screened 49 human colon carcinoma cell lines… CONTINUE READING

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Efstathiou et al

  • M. Ilyas, J. A. Efsthathiou, +4 authors in press. Medical Sciences
  • Proc. Natl. Acad. Sci. USA 96
  • 1999
1 Excerpt

Development (Cambridge, U.K

  • M. Takeichi
  • 1988
1 Excerpt

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