Mutated BRAF Emerges as a Major Effector of Recurrence in a Murine Melanoma Model After Treatment With Immunomodulatory Agents.

@article{Zaidi2015MutatedBE,
  title={Mutated BRAF Emerges as a Major Effector of Recurrence in a Murine Melanoma Model After Treatment With Immunomodulatory Agents.},
  author={S H Manzoor Zaidi and Miran J. Blanchard and Kevin G Shim and Elizabeth J Ilett and Karishma R. Rajani and Christopher R Parrish and Nicolas Boisgerault and Tim Kottke and Jill M Thompson and Esteban Celis and Jose S. Pulido and Peter John Selby and Hardev S. Pandha and Alan A Melcher and Kevin J. Harrington and Richard G. Vile},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2015},
  volume={23 5},
  pages={845-856}
}
We used a VSV-cDNA library to treat recurrent melanoma, identifying immunogenic antigens, allowing us to target recurrences with immunotherapy or chemotherapy. Primary B16 melanoma tumors were induced to regress by frontline therapy. Mice with recurrent tumors were treated with VSV-cDNA immunotherapy. A Th17 recall response was used to screen the VSV-cDNA… CONTINUE READING