Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis

@article{Davis1999MutantsOG,
  title={Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis},
  author={Elizabeth Ann Davis and Antonio Luis Cuesta-Mu{\~n}oz and Morales Raoul and Carol W. Buettger and Ian Sweet and M. Moates and Mark A Magnuson and Franz M. Matschinsky},
  journal={Diabetologia},
  year={1999},
  volume={42},
  pages={1175-1186}
}
Aims/hypothesis. Mutations of the glucokinase gene cause hyperglycaemia or hypoglycaemia. A quantitative understanding of these defects of glucose homeostasis linked to the glucokinase gene was lacking. Therefore a database of kinetic variables of wild-type and 20 missense mutants of glucokinase was developed and used in mathematical modelling to predict the thresholds for glucose-stimulated insulin release. Methods. Recombinant human glucokinase was generated in E. coli. The kcat, glucose S0.5… CONTINUE READING

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