Mutants in the putative nucleotide-binding region of the plasma membrane Ca(2+)-pump. A reduction in activity due to slow dephosphorylation.


Mutants of individual residues of the plasma membrane Ca(2+)-pump were made in the highly conserved region that (in related P-type ATPases) has been associated with nucleotide binding. Alteration of the strictly conserved Asp672 to Glu nearly eliminated the ability of the pump to transport Ca2+, while alteration at Val674, Arg675, and Lys686 reduced the… (More)


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