Mutants and pseudorevertants of Moloney murine leukemia virus with alterations at the integration site.

@article{Colicelli1985MutantsAP,
  title={Mutants and pseudorevertants of Moloney murine leukemia virus with alterations at the integration site.},
  author={John Colicelli and Stephen P Goff},
  journal={Cell},
  year={1985},
  volume={42 2},
  pages={573-80}
}
Soon after infection, retroviruses synthesize a DNA copy of the genomic RNA and insert that DNA into the cellular genome by recombination at inverted repeat sequences at the termini of the viral genome. We have generated mutations that alter one terminus of the genome of Moloney murine leukemia virus (M-MuLV). Some mutations did not prevent integration of the viral DNA even though the very terminal bases were disrupted. Other mutations had dramatic effects on the efficiency of infection; in… CONTINUE READING

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