Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer's disease.

@article{Tijn2012MutantUD,
  title={Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer's disease.},
  author={Paula van Tijn and Frank J. A. Dennissen and Romina J. G. Gentier and Barbara Hobo and Denise J. H. P. Hermes and Harry W. M. Steinbusch and Fred van Leeuwen and David F. Fischer},
  journal={Neurochemistry international},
  year={2012},
  volume={61 5},
  pages={739-48}
}
The mutant ubiquitin UBB(+1) is a substrate as well as an inhibitor of the ubiquitin-proteasome system (UPS) and accumulates in the neuropathological hallmarks of Alzheimer's disease (AD). A role for the UPS has been suggested in the generation of amyloid β (Aβ) plaques in AD. To investigate the effect of UBB(+1) expression on amyloid pathology in vivo, we crossed UBB(+1) transgenic mice with a transgenic line expressing AD-associated mutant amyloid precursor protein (APPSwe) and mutant… CONTINUE READING

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