Mutant tryptophan aporepressors with altered specificities of corepressor recognition.

@article{Arvidson1991MutantTA,
  title={Mutant tryptophan aporepressors with altered specificities of corepressor recognition.},
  author={Dennis N. Arvidson and Marina Shapiro and Philip A. Youderian},
  journal={Genetics},
  year={1991},
  volume={128 1},
  pages={29-35}
}
The Escherichia coli trpR gene encodes tryptophan aporepressor, which binds the corepressor ligand, L-tryptophan, to form an active repressor complex. The side chain of residue valine 58 of Trp aporepressor sits at the bottom of the corepressor (L-tryptophan) binding pocket. Mutant trpR genes encoding changes of Val58 to the other 19 naturally occurring… CONTINUE READING