Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.

  title={Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.},
  author={Felix Meissner and Kaaweh Molawi and Arturo Zychlinsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 29},
ALS is a fatal motor neuron disease of adult onset. Neuroinflammation contributes to ALS disease progression; however, the inflammatory trigger remains unclear. We report that ALS-linked mutant superoxide dismutase 1 (SOD1) activates caspase-1 and IL-1beta in microglia. Cytoplasmic accumulation of mutant SOD1 was sensed by an ASC containing inflammasome and antagonized by autophagy, limiting caspase-1-mediated inflammation. Notably, mutant SOD1 induced IL-1beta correlated with amyloid-like… CONTINUE READING
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