Corpus ID: 13217723

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

@article{Rak1995MutantRO,
  title={Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.},
  author={J. Rak and Y. Mitsuhashi and L. Bayko and J. Filmus and S. Shirasawa and T. Sasazuki and R. Kerbel},
  journal={Cancer research},
  year={1995},
  volume={55 20},
  pages={
          4575-80
        }
}
The growth of solid tumors in vivo beyond 1-2 mm in diameter requires induction and maintenance of an angiogenic response. This can occur through the release of various angiogenic growth factors from tumor cells. One such factor is vascular endothelial growth factor/vascular permeability factor (VEGF/VPF), a secreted and specific mitogen for vascular endothelial cells. We show that one of the most commonly encountered genetic changes detected in human cancer, i.e., expression of mutant ras… Expand

Paper Mentions

Interventional Clinical Trial
Multicenter randomised phase II study of neoadjuvant therapy in HER2 positive early breast cancer. Primary aim is to evaluate the cardiac toxicity of the combined treatment… Expand
ConditionsBreast Cancer
InterventionDrug
Oncogenes as inducers of tumor angiogenesis
Regulation of VEGF/VPF expression in tumor cells: Consequences for tumor growth and metastasis
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