Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.

Abstract

Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and gamma-secretase to release amyloid peptides (Abeta40 and 42) that aggregate to form senile plaques in the brains of patients with Alzheimer's disease (AD). The C-terminus of Abeta40/42 is generated by gamma-secretase, whose activity is dependent upon presenilin (PS 1 or 2… (More)

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@article{Jankowsky2004MutantPS, title={Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.}, author={Joanna L. Jankowsky and Daniel J. Fadale and Jeffrey Anderson and Guilian M. Xu and Victoria Gonzales and Nancy A. Jenkins and Neal G. Copeland and Michael D. Lee and Linda H. Younkin and Steven L. Wagner and Steven G. Younkin and David R Borchelt}, journal={Human molecular genetics}, year={2004}, volume={13 2}, pages={159-70} }