Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis

Abstract

The low molecular weight compound PRIMA-1MET reactivates mutant p53 and triggers mutant p53-dependent apoptosis in human tumor cells. We investigated the effect of PRIMA-1MET on global gene expression using microarray analysis of Saos-2 cells expressing His273 mutant p53 and parental p53 null Saos-2 cells. PRIMA-1MET affected transcription of a… (More)
DOI: 10.1038/onc.2009.425

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