Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells.

@article{Weisz2007MutantPE,
  title={Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells.},
  author={Lilach Weisz and Alexander Damalas and Michalis Liontos and Panagiotis Karakaidos and Giulia Fontemaggi and Revital Maor-Aloni and Marina Kalis and Massimo Levrero and Sabrina Strano and Vassilis G Gorgoulis and Varda Rotter and Giovanni Blandino and Moshe Oren},
  journal={Cancer research},
  year={2007},
  volume={67 6},
  pages={2396-401}
}
Mutations in the p53 tumor suppressor are very frequent in human cancer. Often, such mutations lead to the constitutive overproduction of mutant p53 proteins, which may exert a cancer-promoting gain of function. We now report that cancer-associated mutant p53 can augment the induction of nuclear factor kappaB (NFkappaB) transcriptional activity in response to the cytokine tumor necrosis factor alpha (TNFalpha). Conversely, down-regulation of endogenous mutant p53 sensitizes cancer cells to the… CONTINUE READING