Mutant p53 correlates with reduced expression of thrombospondin-1, increased angiogenesis, and metastatic progression in melanoma.

@article{Grant1998MutantPC,
  title={Mutant p53 correlates with reduced expression of thrombospondin-1, increased angiogenesis, and metastatic progression in melanoma.},
  author={Sarah W Grant and Ainura S Kyshtoobayeva and Tom Kurosaki and James Jakowatz and John P Fruehauf},
  journal={Cancer detection and prevention},
  year={1998},
  volume={22 3},
  pages={185-94}
}
On the basis of reports linking mutant p53 (mp53) to decreased expression of the angiogenesis inhibitor thrombospondin-1 (TSP-1) and increased angiogenesis, we compared primary and metastatic melanoma tumor specimens to determine if these factors were associated with metastatic progression. Western blotting, immunohistochemistry (IHC), and image analysis (IA) techniques were employed to evaluate the relationship between p53 status and TSP-1 expression in Zaz and M14 melanoma cell lines, and… CONTINUE READING