Mutant p53 as a target for cancer treatment.

@article{Duffy2017MutantPA,
  title={Mutant p53 as a target for cancer treatment.},
  author={Michael J. Duffy and N C Synnott and John P. A. Crown},
  journal={European journal of cancer},
  year={2017},
  volume={83},
  pages={258-265}
}
TP53 (p53) is the single most frequently altered gene in human cancers, with mutations being present in approximately 50% of all invasive tumours. However, in some of the most difficult-to-treat cancers such as high-grade serous ovarian cancers, triple-negative breast cancers, oesophageal cancers, small-cell lung cancers and squamous cell lung cancers, p53 is mutated in at least 80% of samples. Clearly, therefore, mutant p53 protein is an important candidate target against which new anticancer… CONTINUE READING
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