Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.

@article{Hult2011MutantHC,
  title={Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.},
  author={Sofia Hult and Rana Soylu and Tomas Bj{\"o}rklund and Bengt F. Belgardt and Jan Mauer and Jens C. Br{\"u}ning and Deniz Kirik and {\AA} Peters{\'e}n},
  journal={Cell metabolism},
  year={2011},
  volume={13 4},
  pages={428-439}
}
In Huntington's disease (HD), the mutant huntingtin protein is ubiquitously expressed. The disease was considered to be limited to the basal ganglia, but recent studies have suggested a more widespread pathology involving hypothalamic dysfunction. Here we tested the hypothesis that expression of mutant huntingtin in the hypothalamus causes metabolic abnormalities. First, we showed that bacterial artificial chromosome-mediated transgenic HD (BACHD) mice developed impaired glucose metabolism and… CONTINUE READING