Mutant huntingtin alters Tau phosphorylation and subcellular distribution.

@article{Blum2015MutantHA,
  title={Mutant huntingtin alters Tau phosphorylation and subcellular distribution.},
  author={D. Blum and F. Herrera and Laetitia Francelle and Tiago Mendes and M. Basquin and H. Obriot and D. Demeyer and N. Sergeant and E. Gerhardt and E. Brouillet and L. Bu{\'e}e and T. Outeiro},
  journal={Human molecular genetics},
  year={2015},
  volume={24 1},
  pages={
          76-85
        }
}
  • D. Blum, F. Herrera, +9 authors T. Outeiro
  • Published 2015
  • Medicine, Biology
  • Human molecular genetics
  • Tau abnormalities play a central role in several neurodegenerative diseases, collectively known as tauopathies. In the present study, we examined whether mutant huntingtin (mHtt), which causes Huntington's disease (HD), modifies Tau phosphorylation and subcellular localization using cell and mouse HD models. Initially, we used novel bimolecular fluorescence complementation assays in live cells to evaluate Tau interactions with either wild type (25QHtt) or mutant huntingtin (103QHtt). While… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 47 CITATIONS, ESTIMATED 55% COVERAGE

    Altered Levels and Isoforms of Tau and Nuclear Membrane Invaginations in Huntington’s Disease

    VIEW 11 EXCERPTS
    CITES BACKGROUND & RESULTS
    HIGHLY INFLUENCED

    Role of Phosphorylated Tau and Glucose Synthase Kinase 3 Beta in Huntington's Disease Progression.

    VIEW 3 EXCERPTS
    CITES RESULTS & BACKGROUND

    Tau and tauopathies

    FILTER CITATIONS BY YEAR

    2015
    2020

    CITATION STATISTICS

    • 4 Highly Influenced Citations

    • Averaged 7 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 53 REFERENCES

    Nuclear Tau, a Key Player in Neuronal DNA Protection*