Mutant huntingtin alters Tau phosphorylation and subcellular distribution.

Abstract

Tau abnormalities play a central role in several neurodegenerative diseases, collectively known as tauopathies. In the present study, we examined whether mutant huntingtin (mHtt), which causes Huntington's disease (HD), modifies Tau phosphorylation and subcellular localization using cell and mouse HD models. Initially, we used novel bimolecular fluorescence… (More)
DOI: 10.1093/hmg/ddu421

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