Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease

@article{RoonMom2008MutantHA,
  title={Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease},
  author={Willeke M. C. van Roon-Mom and Barry A. Pepers and Peter A C 't Hoen and Carola ACM Verwijmeren and Johan T den Dunnen and Josephine C. Dorsman and Gert-Jan van Ommen},
  journal={BMC Molecular Biology},
  year={2008},
  volume={9},
  pages={84 - 84}
}
Huntington's disease is a progressive autosomal dominant neurodegenerative disorder that is caused by a CAG repeat expansion in the HD or Huntington's disease gene. Although micro array studies on patient and animal tissue provide valuable information, the primary effect of mutant huntingtin will inevitably be masked by secondary processes in advanced stages of the disease. Thus, cell models are instrumental to study early, direct effects of mutant huntingtin. mRNA changes were studied in an… CONTINUE READING

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