Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease.

@article{Reddy2012MutantHA,
  title={Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease.},
  author={P. Hemachandra Reddy and Ulziibat P Shirendeb},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1822 2},
  pages={
          101-10
        }
}
Huntington's disease (HD) is a progressive, fatal neurodegenerative disease caused by expanded polyglutamine repeats in the HD gene. HD is characterized by chorea, seizures, involuntary movements, dystonia, cognitive decline, intellectual impairment and emotional disturbances. Research into mutant huntingtin (Htt) and mitochondria has found that mutant Htt interacts with the mitochondrial protein dynamin-related protein 1 (Drp1), enhances GTPase Drp1 enzymatic activity, and causes excessive… CONTINUE READING
Highly Cited
This paper has 60 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

61 Citations

0510'11'13'15'17'19
Citations per Year
Semantic Scholar estimates that this publication has 61 citations based on the available data.

See our FAQ for additional information.