Mutant human cytomegalovirus lacking the immediate-early TRS1 coding region exhibits a late defect.

@article{Blankenship2002MutantHC,
  title={Mutant human cytomegalovirus lacking the immediate-early TRS1 coding region exhibits a late defect.},
  author={Catherine A Blankenship and Thomas E. Shenk},
  journal={Journal of virology},
  year={2002},
  volume={76 23},
  pages={12290-9}
}
The human cytomegalovirus IRS1 and TRS1 open reading frames encode immediate-early proteins with identical N-terminal domains and divergent C-terminal regions. Both proteins have been shown previously to activate reporter genes in transfection assays in cooperation with other viral gene products. We have constructed two viruses carrying substitution mutations within either the IRS1 or TRS1 open reading frame. ADsubIRS1 failed to produce the related IRS1 and IRS1(263) proteins, but it replicated… CONTINUE READING

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