Mutant derivatives of the main respiratory allergen of cow are less allergenic than the intact molecule.

@article{Kauppinen1999MutantDO,
  title={Mutant derivatives of the main respiratory allergen of cow are less allergenic than the intact molecule.},
  author={Jaana M Kauppinen and Thomas Zeiler and Jaakko Rautiainen and M Rytk{\"o}nen-Nissinen and Antti Taivainen and Rauno A. M{\"a}ntyj{\"a}rvi and Tuomas I. Virtanen},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={1999},
  volume={29 7},
  pages={989-96}
}
BACKGROUND Allergen immunotherapy offers an alternative for drug treatment in the management of allergic diseases. Because immunotherapy often induces side-effects, less allergenic preparations would be beneficial. OBJECTIVE The purpose of this study was to examine whether the allergenicity of a cow-derived lipocalin allergen, Bos d 2, could be diminished by substituting or deleting carboxy-terminal amino acids including the cysteine which forms a disulphide bond with a cysteine inside the… CONTINUE READING