Mutant coronavirus in the United Kingdom sets off alarms, but its importance remains unclear

@article{Kupferschmidt2020MutantCI,
  title={Mutant coronavirus in the United Kingdom sets off alarms, but its importance remains unclear},
  author={Kai Kupferschmidt},
  journal={Science},
  year={2020}
}
The high infectivity of SARS-CoV-2 B.1.1.7 is associated with increased interaction force between Spike-ACE2 caused by the viral N501Y mutation
TLDR
This study employed in silico methods involving mutagenesis (N501Y mutation) and interface analysis focusing on the Spike RDB-ACE2 interaction to show that the increased infectivity of SARS-CoV-2 lineage B.1.1-1.7 is associated with the interaction force between the spike RBD Y501 mutant residue with the ACE2 receptor, which in this strain is increased.
Imidazoles and benzimidazoles as putative inhibitors of SARS-CoV-2 B.1.1.7 (Alpha) and P.1 (Gamma) variant spike glycoproteins: A computational approach
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Out of the screened 15 molecules, flubendazole and mebendazoles have exhibited promising binding features to the two receptors, as evidenced by their glide score and binding free energy, and the results are compared with that of the two standard drugs, remdesivir and hydroxychloroquine.
EMERGENCE OF NEW STRAINS OF SARS-COV-2: AFRICA’S FATE AND ITS PREPAREDNESS AGAINST COVID-19 INFECTION WAVES
TLDR
A brief synopsis of the novel SARS-CoV-2, emerging cases of new variants reported worldwide, and implications for genetic surveillance of disease transmission in low- and middle-income countries (LMICs) especially Africa are delivered.
The Role of Information and Communications Technology Policies and Infrastructure in Curbing the Spread of the Novel Coronavirus: Cross-country Comparative Study
TLDR
Investigation of how distancing-enabling information and communications technology infrastructure and medical ICT infrastructure, and related policies have affected the cumulative number of confirmed cases, fatality rate, and initial speed of transmission across different countries demonstrates important relationships between national traits and COVID-19 infections.
Impact of mutations in SARS-COV-2 spike on viral infectivity and antigenicity
TLDR
The spatiotemporal distribution of mutations in spike protein is summarized, and recent efforts and progress in investigating the impacts of those mutations on viral infectivity and antigenicity are presented.
Waves and variants of SARS-CoV-2: understanding the causes and effect of the COVID-19 catastrophe
TLDR
The infectious mechanism of the coronavirus is explained with a focus on different variants and their respective mutations, which play a critical role in the increased transmissibility, infectivity, and immune escape of the virus.
First Report of SARS-CoV-2 Lineage B.1.1.7 (Alpha Variant) in Ecuador, January 2021
TLDR
The patient travelled from the UK by the end of December 2020, and by contact tracing, several new cases were detected confirming B. 1.1.7 transmission and spreading in Ecuador.
A Cross-Country Comparative Study on the Role of Information and Communication Technology Policy and Infrastructure to Curb the Spread of Novel Coronavirus.
TLDR
It is observed that the transmission speed and severity of consequences varied substantially across countries, signaling the need for country-level investigation, and guidelines for policymakers to minimize the negative consequences of pandemics are suggested.
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