Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.

@article{Baer1999MutantCS,
  title={Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.},
  author={Geoffrey Scott Baer and Daniel H. Ebert and Chia J. Chung and Ann Hart Erickson and Terence S Dermody},
  journal={Journal of virology},
  year={1999},
  volume={73 11},
  pages={9532-43}
}
Persistent reovirus infections of murine L929 cells select cellular mutations that inhibit viral disassembly within the endocytic pathway. Mutant cells support reovirus growth when infection is initiated with infectious subvirion particles (ISVPs), which are intermediates in reovirus disassembly formed following proteolysis of viral outer-capsid proteins. However, mutant cells do not support growth of virions, indicating that these cells have a defect in virion-to-ISVP processing. To better… CONTINUE READING