Mutant and infectious prion proteins display common biochemical properties in cultured cells.

@article{Lehmann1996MutantAI,
  title={Mutant and infectious prion proteins display common biochemical properties in cultured cells.},
  author={Sylvain Lehmann and David A Harris},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 3},
  pages={
          1633-7
        }
}
Prion diseases are unusual neurodegenerative disorders that can be both infectious and inherited. Both forms are hypothesized to result from a posttranslational structural alteration in the cell surface glycoprotein PrPc (cellular isoform of the prion protein) that converts it into the protease-resistant isoform PrPSc (scrapie isoform of the prion protein). However, a direct comparison of molecular events underlying these two manifestations of prion diseases has not been possible, because there… CONTINUE READING
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