Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

Abstract

Proteins enter the secretory pathway through the endoplasmic reticulum, which delivers properly folded proteins to their site of action and contains a quality-control system to monitor and prevent abnormal proteins from being delivered. Many of these proteins are degraded by the cytoplasmic proteasome, which requires their retrograde transport to the… (More)
DOI: 10.1038/42276

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