Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.

@article{Yang2015MutantAC,
  title={Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.},
  author={Weili Yang and Guohao Wang and Chuan-en Wang and Xiangyu Guo and Peng Yin and Jinquan Gao and Zhuchi Tu and Zhengbo Wang and Jing Wu and Xintian Hu and Shihua Li and Xiao-Jiang Li},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 21},
  pages={
          8345-58
        }
}
Parkinson's disease (PD) is an age-dependent neurodegenerative disease that often occurs in those over age 60. Although rodents and small animals have been used widely to model PD and investigate its pathology, their short life span makes it difficult to assess the aging-related pathology that is likely to occur in PD patient brains. Here, we used brain tissues from rhesus monkeys at 2-3, 7-8, and >15 years of age to examine the expression of Parkin, PINK1, and α-synuclein, which are known to… CONTINUE READING

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