Mutant allele‐specific imbalance modulates prognostic impact of KRAS mutations in colorectal adenocarcinoma and is associated with worse overall survival

@article{Hartman2012MutantAI,
  title={Mutant allele‐specific imbalance modulates prognostic impact of KRAS mutations in colorectal adenocarcinoma and is associated with worse overall survival},
  author={D. Hartman and J. Davison and T. Foxwell and M. Nikiforova and S. Chiosea},
  journal={International Journal of Cancer},
  year={2012},
  volume={131}
}
The prognostic impact of distinct KRAS mutations in colorectal carcinomas is not fully characterized. We hypothesized that the prognostic impact of KRAS mutations is modulated by KRAS mutant allele‐specific imbalance (MASI). KRAS MASI was assessed by sequencing electropherograms in KRAS‐mutated colorectal carcinomas (N = 394, prospectively tested). The mechanism of KRAS MASI was studied by fluorescence in situ hybridization (FISH; N = 50). FISH showed that KRAS MASI developed by chromosome 12… Expand
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