Mutant WDR36 directly affects axon growth of retinal ganglion cells leading to progressive retinal degeneration in mice

@inproceedings{Chi2010MutantWD,
  title={Mutant WDR36 directly affects axon growth of retinal ganglion cells leading to progressive retinal degeneration in mice},
  author={Zai-Long Chi and Fumie Yasumoto and Yuri Sergeev and Masayoshi Minami and Minoru Obazawa and Itaru Kimura and Yuichiro Takada and Takeshi Iwata},
  booktitle={Human molecular genetics},
  year={2010}
}
Primary open-angle glaucoma (POAG) is one of the three principal subtypes of glaucoma and among the leading cause of blindness worldwide. POAG is defined by cell death of the retinal ganglion cells (RGCs) and surrounding neuronal cells at higher or normal intraocular pressure (IOP). Coded by one of the three genes responsible for POAG, WD repeat-containing protein 36 (WDR36) has two domains with a similar folding. To address whether WDR36 is functionally important in the retina, we developed… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Similar Papers

Loading similar papers…