Mutant U2 snRNAs of Xenopus which can form an altered higher order RNA structure are unable to enter the nucleus.

@article{Konings1987MutantUS,
  title={Mutant U2 snRNAs of Xenopus which can form an altered higher order RNA structure are unable to enter the nucleus.},
  author={Danielle A. M. Konings and Iain W Mattaj},
  journal={Experimental cell research},
  year={1987},
  volume={172 2},
  pages={
          329-39
        }
}
We studied the nuclear targeting of U snRNAs by microinjection of wild-type and mutant U2 small nuclear RNA transcripts into the cytoplasm of Xenopus oocytes. It has previously been shown that a mutant U2 RNA (delta C) which does not bind certain common U snRNP proteins, some of which carry epitopes recognized by anti-Sm antisera, does not enter the nucleus. We show here that several mutant U2 RNAs which bind to Sm antigens do not enter the nucleus, demonstrating that this RNA-protein… CONTINUE READING

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