Mutant Sod1-expressing Astrocytes Release Toxic Factors That Trigger Motor Neuron Death


42 Amyotrophic lateral sclerosis (ALS) is a devastating paralytic disorder caused by dysfunction 43 and degeneration of motor neurons starting in adulthood. Recent studies using cell or animal 44 models document that astrocytes expressing disease-causing mutations of human 45 superoxide dismutase 1 (hSOD1) contribute to the pathogenesis of ALS by releasing… (More)


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