Mutant Sod1-expressing Astrocytes Release Toxic Factors That Trigger Motor Neuron Death

Abstract

42 Amyotrophic lateral sclerosis (ALS) is a devastating paralytic disorder caused by dysfunction 43 and degeneration of motor neurons starting in adulthood. Recent studies using cell or animal 44 models document that astrocytes expressing disease-causing mutations of human 45 superoxide dismutase 1 (hSOD1) contribute to the pathogenesis of ALS by releasing… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics